fibrinogen/fibrin system for greater control of fibrin polymerization and degradation. In R21EB008463, we hypothesized that a fibrin knob fusion with thermo-responsive elastin-like peptide repeats will bind to fibrinogen polymerization pockets and prevent polymerization

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چکیده

Our long-term research goal is to understand and exploit the natural biochemical properties of the fibrinogen/fibrin system for greater control of fibrin polymerization and degradation. In R21EB008463, we hypothesized that a fibrin knob fusion with thermo-responsive elastin-like peptide repeats will bind to fibrinogen polymerization pockets and prevent polymerization in a temperature-dependent manner. We proposed 2 specific aims to address this hypothesis; SA1) design and express recombinant proteins displaying N-terminal fibrin polymerization knobs, and SA2) create recombinant knob-ELP fusion proteins and test their fibrinogenbinding/fibrin blocking activity.

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تاریخ انتشار 2011